Ellagic Acid - Clinical Studies
The Hollings Cancer Institute at the University of South Carolina completed a double blind study on a large group of 500 cervical
cancer patients that has everyone excited. Nine years of study have shown that ellagic acid is causing G-arrest within 48 hours (inhibiting and stopping mitosis-cancer cell division), and
apoptosis (normal cell death) within 72 hours, for breast, pancreas, esophageal, skin, colon and prostate cancer cells.
Clinical tests also show that ellagic acid prevents the destruction of the p53 gene by cancer cells (p53 are regarded as the safeguard of mutagenic activity in cervical cells.) Additional
studies suggest that one of the mechanisms by which ellagic acid inhibits mutagenesis and carcinogenesis is by forming adducts with DNA, thus masking binding sites to be occupied by the
mutagen or carcinogen.
The Hollings Clinic has identified the Meeker Red Raspberry for their studies.
Our product is only made from Meeker's red raspberry seed flour.
Other Studies come from: College of Medicine, University of Illinois Northwestern University School of Medicine Department of Preventive Medicine, Ohio State University.
Ellagic Acid - Mode of Action
Ellagic Acid itself is not naturally present in plants. However, polymers of Gallic acid and hexahydroxydipenoyl (HHDP) are linked to glucose centers to form compounds known as ellagitannins.
When two Gallic acid groups are linked side by side within a tannin molecule an HHDP group is formed. Ellagic Acid is the result when the HHDP group is cleaved from the tannin molecule and
spontaneously rearranges.
It is the ellagitannins that are present in red raspberries.
The Meeker Red Raspberry contains the most ellagitannins and is thus the best source of Ellagic Acid.
Other foods such as strawberries, pomegranates, and walnuts contain much less amounts of Ellagitannins. The bioavailability from these other sources has not been confirmed.
Ellagic acid is a scavenger of cancer-causing chemicals, making them inactive, inhibiting the ability of other chemicals to cause mutations in bacteria. Additionally, Ellagic Acid from red
raspberries prevents binding of carcinogens to DNA, and reduces the incidence of cancer in cultured human cells exposed to carcinogens. |
Ellagic Acid - Background
Ellagic Acid - History
Ellagic Acid - Evidence
Ellagic Acid - Clinical Studies
Ellagic Acid - Mode of Action
Ellagic Acid - Medical References
Ellagic Acid - Med. References cont.
Ellagic Acid - Reference Papers
General Health - Resources |
